- PII
- 10.31857/S0026365624020275-1
- DOI
- 10.31857/S0026365624020275
- Publication type
- Status
- Published
- Authors
- Volume/ Edition
- Volume 93 / Issue number 2
- Pages
- 244-246
- Abstract
- A total of 397 Mycobacterium tuberculosis strains isolated from newly diagnosed patients with pulmonary tuberculosis in the Omsk region in 2019‒2020 were genotyped. The prevalence of strains of the Beijing genotype (70.8%) was established, in particular of two clusters of the modern sublineage — Central Asian/Russian (46.1%) and B0/W148 (19.1%). Strains of the ancient sublineage of the Beijing genotype were represented by clusters 1071-32 and 14717-15, totaling 4.8%. Compared with other genotypes, B0/W148 cluster and the ancient Beijing sublineage were associated with multidrug resistance (MDR): 93.4% and 94.7%, respectively (P < 0.0001). Among representatives of other genetic families (LAM, Ural, T, Haarlem), drug-sensitive strains predominated (75.0%). The circulation of MDR Beijing strains requires molecular epidemiological surveillance in view of their possible wider spread.
- Keywords
- Mycobacterium tuberculosis множественная лекарственная устойчивость генотип Beijing
- Date of publication
- 15.03.2024
- Year of publication
- 2024
- Number of purchasers
- 0
- Views
- 36
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