- PII
- 10.31857/S0026365624020247-1
- DOI
- 10.31857/S0026365624020247
- Publication type
- Status
- Published
- Authors
- Volume/ Edition
- Volume 93 / Issue number 2
- Pages
- 228-233
- Abstract
- Infections associated with biofilm formation by gram-positive and gram-negative microorganisms cause difficulty in therapy and are prone to transition into chronic forms. Approaches to degradation of the biofilm matrix are therefore in demand. In the present work, recombinant recombinant PAPC serine protease from Aspergillus ochraceus caused the degradation of mature biofilms formed by a number of gram-positive and gram-negative bacteria by 15‒20% at 50 µg/mL. At 100 µg/mL, the biomass of S. aureus and P. aeruginosa biofilms decreased by 50%. Thus, the PAPC may be a promising agent for biofilm removal and enhance the efficiency of antimicrobial therapy.
- Keywords
- протеолитические ферменты бактериальные биопленки устойчивость к противомикробным препаратам разрушение биопленок
- Date of publication
- 15.03.2024
- Year of publication
- 2024
- Number of purchasers
- 0
- Views
- 45
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